![]() ![]() This study was conducted in conjunction with the work published by Pereira et al.,(3) which has been approved by the Ethics Committee on the Use of Animals of the State University at Campinas Institute of Biology (Reference no. We evaluated numerical variables (Table 1) and curves (Figures 1A, 1B, and 1C). Our aim was to record, observe, and analyze the behavior of respiratory mechanics parameters, especially VCap data. ![]() ![]() This was an observational study of pigs induced to MPE through the injection of autologous clots, during spontaneous ventilation (FiO2 = 0.21). The respiratory profile monitor (CO2SMO PLUS DX-8100 Respironics, Murrysville, PA, USA) provides and records variables such as end-tidal partial pressure of CO2 (PetCO2), CO2 output (VCO2), the phase II slope of the capnogram (SII), the phase III slope of the capnogram (SIII)―also known as the alveolar plateau, respiratory rate (RR), inspiratory tidal volume (VTi), expiratory tidal volume (VTe), inspiratory time, expiratory time, alveolar minute volume (MValv), peak inspiratory flow, and peak expiratory flow. To address the clinical scenario of MPE, one may make use of noninvasive devices with software that monitors respiratory mechanics and volumetric capnography (VCap) data, online and offline, providing information that may indicate ventilation-perfusion mismatch, in MPE or in other diseases. They can also indicate whether the MPE is likely to improve or not. Methods that detect those changes in real time, especially noninvasive ones, can be very useful. Massive pulmonary embolism (MPE) is a condition that causes sudden changes to the cardiopulmonary system(1-5) and is associated with high morbidity and mortality. ![]()
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